President Donald Trump listens as Dr. Marty Makary, commissioner of the Food and Drug Administration, speaks in the Roosevelt Room of the White House, Monday, Sept. 22, 2025, in Washington.Mark Schiefelbein/AP
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President Donald Trump’s Food and Drug Administration commissioner Marty Makary resigned on Tuesday following political battles over health policy that angered anti-abortion activists and industry executives.
Makary, who led the agency in charge of promoting public health through regulating food safety, medications, tobacco, vaccines, and more, stepped down after Trump pushed him to approve fruit-flavored vapes earlier this month. According to the Wall Street Journal, advisers told the president that flavored vaping was important to young MAGA voters. Makary resisted the idea, but last Friday, the FDA adopted a new policy that opens the door for tobacco and vape companies to sell the e-cigarettes anyway.
Makary also faced criticism from anti-abortion groups who demanded the FDA reverse their approval of the abortion drug mifepristone, which is used in most abortions, to be given out without requiring an in-person visit. A federal court ordered a nationwide in-person requirement earlier this month, and the Supreme Court is still reviewing the decision. Last week, it temporarily reinstated mifepristone access through telemedicine and mail.
This latest resignation opens up another hole in the Trump administration, which has not yet appointed a permanent Centers for Disease Control and Prevention director and a surgeon general to Robert F. Kennedy’s health department. Trump has also axed other key officeholders for failing to do his bidding, like former attorney general Pam Bondi and former Homeland Security secretary Kristi Noem.
Trump confirmed Makary’s exit on Tuesday afternoon ahead of his trip to China to speak with President Xi Jinping. “He was having some difficulty. He’s a great doctor. He’s going to go on and do well,” Trump told reporters. “Everybody wants that job.”
Makary was perhaps an attractive FDA commissioner candidate to Trump due in part to his anti-abortion views and promise to quickly transform policy. As Julianne McShane wrote for Mother Jones when Makary was confirmed last March, the FDA commissioner has spread misinformation, including telling ex-Fox News host Tucker Carlson that fetuses feel pain in utero several weeks before science indicates.
This was not enough for Trump and his far right supporters.
Kyle Diamantas, a deputy commissioner within the FDA, will become the acting head of the federal agency, according to Politico, which first reported Makary’s resignation. Whether Diamantas—or whoever is confirmed next—follows the Trump administration’s lead remains to be seen.
