Holders Hull KR will visit fellow Super League side Huddersfield Giants in round four of the Challenge Cup.
Wakefield Trinity host Leeds Rhinos in a West Yorkshire derby while St Helens visit Castleford Tigers.
Wigan, who have won a record 21 finals, welcome Bradford Bulls, who returned to Super League this season for the first time since 2014.
Championship side Oldham will take a trip to Perpignan to face Catalans Dragons and Leigh Leopards face Hull FC.
Meanwhile the lowest ranked side in the draw, Goole Vikings, have a home tie against Warrington Wolves with all 14 Super League clubs still in the competition.
The ties will take place on the weekend of 14-15 March with the specific dates yet to be decided.
The final will be held at Wembley Stadium on Saturday, 30 May.
